1. What is Iron Saturation (TSAT)?

Transferrin saturation (TSAT) is a medical laboratory value that represents the percentage of iron-binding sites on transferrin that are occupied by iron. It is calculated by dividing serum iron by total iron-binding capacity (TIBC) and multiplying by 100.

2. How Does the Calculator Work?

The calculator uses the TSAT formula:

Where:

• \( Iron \) — Serum iron concentration (μg/dL)
• \( TIBC \) — Total iron-binding capacity (μg/dL)

Explanation: This calculation measures the percentage of transferrin that is saturated with iron, providing important information about iron status in the body.

3. Importance of TSAT Calculation

Details: TSAT is a crucial parameter in the diagnosis and management of iron deficiency anemia, iron overload conditions, and helps guide iron replacement therapy decisions.

4. Using the Calculator

Tips: Enter serum iron and TIBC values in μg/dL. Both values must be valid (greater than 0). The calculator will provide the transferrin saturation percentage.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal TSAT range?
A: Normal TSAT ranges from 20% to 50%. Values below 20% suggest iron deficiency, while values above 50% may indicate iron overload.

Q2: How does TSAT differ from ferritin?
A: TSAT measures functional iron available for erythropoiesis, while ferritin reflects iron storage. Both are important in assessing iron status.

Q3: When should TSAT be measured?
A: TSAT is typically measured when evaluating anemia, monitoring iron therapy, or assessing for iron overload conditions like hemochromatosis.

Q4: Are there limitations to TSAT measurement?
A: TSAT can fluctuate throughout the day and may be affected by recent iron intake, inflammation, or liver disease.

Q5: How is TSAT used in clinical practice?
A: TSAT helps diagnose iron deficiency anemia, guide iron supplementation, monitor response to therapy, and screen for hereditary hemochromatosis.